Estradiol valerate (EV), sold for use by mouth under the brand name Progynova and for use by injection under the brand names Delestrogen and Progynon Depot among others, is an estrogen medication. How is estradiol valerate administered? Estradiol Valerate Injection, USP contains estradiol valerate, a long-acting estrogen in sterile oil solutions for intramuscular injection.1 Estradiol valerate (Delestrogen) injection is a hormone replacement therapy (HRT). It's used to relieve certain menopause symptoms, such as hot flashes and vaginal dryness. Estradiol Valerate is a trusted and effective form of oestrogen used in gender-affirming therapy to help transgender women and non-binary individuals achieve physical changes aligned with their gender identity. Discover the benefits of Estradiol Valerate for menopause, HRT, and transgender care. Learn about dosages, side effects, and proper injection techniques. Clinical studies of estradiol valerate did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Estradiol Valerate Injection package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. This guide covers oral estradiol tablets only. Estradiol is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women. Estradiol Valerate Injection, USP contains estradiol valerate, a long-acting estrogen in sterile oil solutions for intramuscular use. These solutions are clear, colorless to yellow. It is used after menopause to reduce vaginal dryness, pain during sex, hot flashes, night sweats, prevent osteoporosis, and to treat advanced prostate cancer. The tablets are also used to treat.