Estradiol valerate (Delestrogen) injection is an injection that's given into the muscle every 1-4 weeks depending on the reason you're taking it. Potential side effects include vaginal spotting, breast tenderness, and headache. Find patient medical information for Estradiol (Delestrogen, Depo-Estradiol, Estrace) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings DESCRIPTION DELESTROGEN® (estradiol valerate injection, USP) contains estradiol valerate, a long-acting estrogen in sterile oil solutions for intramuscular use. These solutions are clear, colorless to yellow. Formulations (per mL): 10 mg estradiol valerate in a vehicle containing 5 mg chlorobutanol (chloral derivative/preservative) and 915 mg sesame oil; 20 mg estradiol valerate in a vehicle. Estradiol Valerate is a long-acting injectable and oral oestrogen commonly used in gender-affirming hormone therapy for transgender women and non-binary people. It promotes feminization through sustained hormone release, supporting breast development, fat redistribution, and emotional well-being. Estradiol valerate (EV), sold for use by mouth under the brand name Progynova and for use by injection under the brand names Delestrogen and Progynon Depot among others, is an estrogen medication. Estradiol Valerate Injection package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Discover the benefits of Estradiol Valerate for menopause, HRT, and transgender care. Learn about dosages, side effects, and proper injection techniques. Estradiol is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning and irritation. Includes estradiol side effects, interactions and indications. Estradiol Valerate Injection, USP contains estradiol valerate, a long-acting estrogen in sterile oil solutions for intramuscular use. These solutions are clear, colorless to yellow. Learn about estradiol valerate, its uses in hormone replacement therapy, potential side effects, and dosage recommendations.